Does Semaglutide Make You Tired? Other Potential Side Effects

What is semaglutide? You might have heard this name if you know someone with diabetes or who is trying to lose weight. Semaglutide is a medicine that is becoming very popular because it works well. But, like all medicines, it can have side effects. One big question people have is: Does semaglutide make you feel tired? Let’s look into this and find out more.

What is Semaglutide?

Semaglutide is a medicine classified as a GLP-1 receptor agonist. It works by mimicking GLP-1, a hormone found in your body that helps manage blood sugar levels. It is extensively used to treat type 2 diabetes and, more recently, to lose weight. The benefits of semaglutide include improved blood sugar control and significant weight loss, which is why it is gaining popularity.

Must Read: How to Inject Semaglutide? Best Place To Inject

What are the Common Side Effects of Semaglutide?

While semaglutide is generally well-tolerated, it can cause a range of side effects. The most common ones include:

1. Gastrointestinal Issues

The most often reported side effects were nausea, vomiting, and diarrhea. These symptoms frequently appear when patients first begin taking the medicine or when the dose is increased. They tend to reduce with time as the body gets used to the medicine.


Nausea is the most prevalent gastrointestinal adverse effect. It is usually mild to severe, and can be treated by starting with a low dose and progressively increasing it. Eating smaller, more frequent meals and avoiding high-fat foods can also assist with nausea.


Vomiting may accompany nausea, particularly at the start of treatment. Staying hydrated and adhering to dietary guidelines can help relieve this problem. If you continue to vomit, you should see a doctor.


Diarrhea is another typical side effect associated with semaglutide treatment. It is usually moderate but can be irritating. Patients should stay hydrated and seek medical attention if the diarrhea is severe or prolonged.

2. Abdominal Pain

Some people may experience stomach pain or discomfort. This could be attributed to the delay in stomach emptying, which is how semaglutide controls appetite. If the discomfort is severe or persistent, get medical attention.

Related: 10 Reasons of Pain in Lower Abdomen When Cough

3. Decreased Appetite

While a decrease in appetite might be good for those trying to reduce weight, it can also result in unwanted weight loss or nutritional inadequacies. Dietary intake should be monitored to ensure enough nutrition.

4. Hypoglycemia

Patients using other diabetes drugs, particularly insulin or sulfonylureas, are at risk of developing hypoglycemia (low blood sugar levels). Symptoms of hypoglycemia include perspiration, dizziness, confusion, and palpitations. Blood sugar levels must be monitored on a regular basis, and other diabetic medications should be adjusted accordingly.

What are the Common Side Effects of Semaglutide?

The Link Between Semaglutide and Fatigue

Semaglutide is primarily prescribed to treat type 2 diabetes. While it is generally well tolerated, it might cause negative effects, just like any other medication. Fatigue is one potential negative effect of semaglutide use. Some people may feel tired or have less energy after taking semaglutide.

The specific mechanism by which semaglutide can cause tiredness is not entirely understood. However, it is thought to be related to how the medicine affects specific hormones and neurotransmitters in the body, which can affect energy levels and weariness.

If a person develops persistent or severe fatigue while taking semaglutide, they should consult their healthcare professional. The healthcare provider can determine whether the fatigue is caused by the drug or by other factors. Depending on the circumstances, the healthcare professional may adjust the dosage of semaglutide or consider alternate treatments.

Does Semaglutide Make You Tired?

Yes, semaglutide might cause tiredness or fatigue as a side effect. While not everyone has this side effect, some people may feel more tired or have less energy after taking semaglutide.

If someone experiences persistent or severe fatigue while taking semaglutide, they should consult with their doctor. They can determine if the fatigue is due to the medicine and make any required changes to the treatment plan.

Does Semaglutide Make You Tired?

Why Do You Feel Tired While Taking Semaglutide?

Semaglutide is primarily prescribed to treat type 2 diabetes. While semaglutide does not typically cause tiredness, some people may suffer fatigue or tiredness as a side effect. There are a few possible explanations for this:

  1. Blood sugar fluctuations: Semaglutide works by lowering blood sugar levels, and if your blood sugar falls too low, you may become weary or lethargic. Monitor your blood sugar levels on a regular basis and discuss any substantial changes with your healthcare physician.
  2. Digestive problems: When using semaglutide, some patients have gastrointestinal symptoms such as nausea, diarrhea, or indigestion. These symptoms might cause sensations of exhaustion or fatigue due to abnormalities in digestion and nutrient absorption.
  3. Adjustment period: When starting semaglutide or changing the dosage, your body may require time to adjust to the medicine. During this adjustment period, you may feel more weary than usual, but this should subside as your body adjusts to the drug.
  4. Other issues: Fatigue can be influenced by causes other than semaglutide, such as stress, poor sleep quality, or drugs you may be taking.

How Do You Get Rid of Fatigue From Semaglutide?

If you are feeling fatigue or tired while taking semaglutide, you can take the following steps to help control it:

  1. Stay hydrated: Dehydration can contribute to feelings of exhaustion, so drink plenty of water throughout the day.
  2. Eat regularly: Follow a balanced diet with regular meal times to help regulate your blood sugar levels and provide your body with the energy it requires.
  3. Monitor blood sugar levels: Keep track of your blood sugar levels as directed by your doctor. If you detect any substantial fluctuations, speak with your doctor.
  4. Get enough sleep: Aim for 7-9 hours of good sleep each night. To promote better sleep, establish a nightly ritual and make your sleeping environment comfortable.
  5. Manage stress: Stress can worsen exhaustion, so use relaxation techniques like deep breathing, meditation, or yoga to help reduce stress levels.
  6. Exercise on a regular basis: Physical activity can increase your vitality and overall well-being. Aim for at least 30 minutes of moderate exercise most days of the week, but consult your doctor before beginning any new exercise regimen.
  7. Review medication: If you believe semaglutide is causing your exhaustion, speak with your doctor. They may change your dosage or look into alternate treatment alternatives.
  8. Address other health issues: Fatigue can be a symptom of a variety of health conditions, so discuss any underlying issues with your doctor.
How Do You Get Rid of Fatigue From Semaglutide?

Other Potential Side Effects of Semaglutide?

1. Pancreatitis

Pancreatitis, or inflammation of the pancreas, is a dangerous but uncommon adverse effect. Symptoms include severe abdominal discomfort, nausea, vomiting, and a rapid heart rate. If pancreatitis is suspected, quit semaglutide immediately and seek medical assistance.

2. Kidney Problems

Some individuals’ kidney function may deteriorate, particularly those with pre-existing kidney problems. Kidney disorders can be identified by changes in urine production, edema in the legs and ankles, and weariness. Patients on Semaglutide should have their renal function monitored on a regular basis.

3. Thyroid Tumors

In animal studies, semaglutide has been linked to an increased incidence of thyroid cancers, particularly medullary thyroid carcinoma (MTC). Although this risk has not been verified in humans, patients with a personal or family history of MTC or Multiple Endocrine Neoplasia Syndrome type 2 (MEN 2) should avoid using Semaglutide.


In short, semaglutide can make some people feel really tired, but it doesn’t happen to everyone. Knowing why it makes you tired and how to handle it can help a lot. Always talk to your doctor if you have any worries, and they can help you find the best way to get the good parts of the medicine without feeling too tired.

People Also Ask

1. What is Semaglutide and why might it make me tired?

Semaglutide is a medication commonly used to help diabetics maintain their blood sugar levels. Some people who use Semaglutide feel weary as their bodies acclimate to the medication. It’s similar to starting a new school regimen; your body may need some time to adjust to the shift.

2. Is feeling tired a common side effect of Semaglutide?

Yes, feeling fatigued is a common side effect when you first begin taking Semaglutide. Imagine starting a new workout; your muscles may feel sore and weary at first. Similarly, your body may feel fatigued while it adjusts to Semaglutide.

3. How long will the tiredness last after taking Semaglutide?

Semaglutide-induced fatigue usually passes quickly. It’s similar to how your body adjusts to a new nighttime routine—it may be difficult at first, but it gets easier over time. Most people begin to feel less weary after a few weeks.

4. What can I do to feel less tired while taking Semaglutide?

To feel less fatigued, try to get enough sleep, consume healthy foods, and drink plenty of water. Consider it similar to caring for a plant: it requires water, sunlight, and suitable soil to thrive. Taking care of your body can make you feel less exhausted.

5. Should I tell my doctor if Semaglutide makes me very tired?

Yes, if Semaglutide causes you to feel extremely sleepy, you should notify your doctor. It’s similar like informing a teacher if you’re having difficulties with your homework; they can give you advice or modify your medication to help you feel better. Your doctor can help you make sure you’re taking the proper quantity and determine whether something else would be more effective for you.

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