Can You Take Nyquil with Amoxicillin?

If you have a cold or flu and need to take medicine like amoxicillin for a bacterial infection, you might want to know if it’s okay to also take Nyquil. Both medicines help you feel better, but it can be dangerous to mix them if you don’t know if they work well together. Let’s see if it’s safe to take Nyquil with amoxicillin.

What is Nyquil?

Nyquil is a popular over-the-counter medicine that works well to relieve cold, flu, and allergy symptoms. Acetaminophen (a pain reliever/fever reducer), dextromethorphan (a cough suppressant), doxylamine (an antihistamine), and, in some cases, phenylephrine (a nasal decongestant) are common components.

How Nyquil Works

NyQuil is an over-the-counter medicine intended to treat symptoms of colds, allergies, and the flu. It is a combination medicine that usually includes many active components, such as:

  1. Acetaminophen: This chemical reduces fever and relieves minor aches and pains.
  2. Dextromethorphan: It is a cough suppressant that helps to relieve coughing.
  3. Doxylamine succinate: It is an antihistamine that reduces symptoms including sneezing, runny nose, and watery eyes by inhibiting the activity of histamine, a chemical produced by the body during an allergic reaction.
  4. Phenylephrine: Some NyQuil formulations may additionally include phenylephrine, a decongestant that relieves nasal congestion by reducing enlarged blood vessels in the nasal passages.
How Nyquil Works

What is Amoxicillin?

Amoxicillin is a regularly prescribed antibiotic that treats bacterial infections. It belongs to the penicillin group of antibiotics and acts by interfering with the bacteria’s ability to construct cell walls, eventually killing them.

Amoxicillin is effective against a variety of bacterial infections, including those of the ears, nose, throat, sinuses, lungs, skin, and urinary tract.

Purpose and Usage

Amoxicillin works by preventing the growth of bacteria, allowing the body’s immune system to combat the illness. It is normally taken orally in the form of capsules, pills, or oral suspension, with the dosage and duration of treatment determined by the kind and severity of the infection.

How Amoxicillin Works?

Amoxicillin works by interfering with bacteria’s capacity to form cell walls, eventually resulting to their death. It belongs to the penicillin antibiotic class, which inhibits the formation of peptidoglycan, a critical component of bacterial cell walls.

Bacterial cell walls offer structure and protection to the cell; without them, bacteria cannot keep their form and integrity, resulting in their demise. Amoxicillin acts by suppressing the activity of transpeptidases, enzymes that cross-link peptidoglycan chains in bacterial cell walls.

Amoxicillin weakens the cell wall by interfering with this process, making it more prone to harm and eventually resulting in bacterial cell death.

Can Nyquil and Amoxicillin Be Taken Together?

It is normally safe to take Nyquil and Amoxicillin together, but always contact with a doctor before mixing drugs. Nyquil has several chemicals, including paracetamol, dextromethorphan, and doxylamine, among others. These components can help relieve symptoms including discomfort, coughing, and congestion caused by colds or flu.

Amoxicillin is an antibiotic that treats bacterial infections. It is critical to finish the entire course of antibiotics given by your healthcare professional, even if you begin to feel better before the medicine is finished.

While there are no known interactions between Nyquil and Amoxicillin, it is still recommended that you consult with a healthcare professional or pharmacist to ensure there are no special concerns based on your medical history or other medications you may be taking. Additionally, avoid drinking alcohol while taking Nyquil, as it contains alcohol and may increase its sleepy effects.

Can Nyquil and Amoxicillin Be Taken Together?

Can You Take Nyquil and Benadryl?

It is generally not suggested to combine Nyquil (which contains chemicals such as acetaminophen, dextromethorphan, and doxylamine) and Benadryl (which contains diphenhydramine) without first consulting a healthcare practitioner.

Fatyfit indicates that both drugs can produce drowsiness and sedation, and taking them together might amplify these effects, potentially resulting in extreme sleepiness, dizziness, disorientation, and other side effects.

Taking them together may also increase the chance of adverse effects such as blurred vision, dry mouth, constipation, urine retention, and cognitive impairment. Furthermore, these medications may interact with other prescriptions.

So consult your doctor or pharmacist before combining them, especially if you are taking other medications or have underlying health concerns.

What About Taking Ibuprofen With Amoxicillin?

Most people consider it safe to use ibuprofen and amoxicillin together because there are no known interactions between the two drugs. Ibuprofen is a nonsteroidal anti-inflammatory medicine (NSAID) that relieves pain and inflammation, whereas amoxicillin is an antibiotic that treats bacterial infections.

However, it is always advisable to talk with a healthcare practitioner before mixing any medications, especially if you have any underlying health concerns or are currently taking other prescriptions.

Most people can safely take ibuprofen and amoxicillin together. But if you’ve had stomach ulcers or bleeding in your gut before, it might not be a good idea for you.

More: Can I Use Expired Eye Drops?


So, when you’re sick, Nyquil and amoxicillin can help you feel better. But it’s important to be careful if you want to take them both at the same time. You should talk to your doctor before doing that. They’ll make sure it’s safe and won’t cause any problems for you.

Frequently Asked Questions

Can I take Nyquil while on Amoxicillin?

It is advised to avoid taking Nyquil while on Amoxicillin unless your doctor approves. Combining these two medications may be unsafe and cause undesired side effects.

What happens if I mix Nyquil and Amoxicillin?

Combining Nyquil with Amoxicillin may result in dizziness, sleepiness, and other adverse effects. Before combining these medications, consult your doctor or pharmacist to ensure your safety.

Is it safe to take Nyquil Cold and Flu with Amoxicillin?

It is typically not recommended that you take Nyquil Cold and Flu with Amoxicillin without first seeing your doctor. These medications can interact in ways that are not necessarily safe for everyone.

Can I drink alcohol while taking Amoxicillin and Nyquil?

Alcohol consumption while taking Amoxicillin and Nyquil increases the risk of adverse effects such as dizziness and drowsiness. It is advised to avoid alcohol completely while taking these drugs.

How long should I wait after taking Amoxicillin before I can take Nyquil?

To be safe, wait until you’ve finished your Amoxicillin before taking Nyquil. This allows you to avoid any potential interactions between the two medications. If you’re not sure when to take your medications, always check your doctor or pharmacist.

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